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Selected Preclinical Data Study 1: Genetic Proof-of-Concept A seminal investigation reported elevated NNMT expression in white adipose tissue (WAT) and liver of obese/diabetic mice

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The exact mechanism remains unresolved after decades: no specific receptor, precursor gene, or biosynthetic pathway has been definitively identified

Pathological features of cerebral cortical capillaries are doubled in Alzheimers disease and Parkinsons disease

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