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In addition to normal tissues, it has been reported that GPx2 is upregulated in a variety of tumor cells [76, 95] and is associated with tumor cell proliferation and poor prognosis of patients [96, 97]

At present, it remains unclear whether these changes in PSCs contribute to the development of pancreatitis seen in patients with chronic use of GLP-1R agonists, or whether they could lead to complications of the increased PSCs proliferation due to long-term use of GLP-1 agonists

However, in the striatum, which is located in the subcortical forebrain, insulin influences dopamine reuptake and release, with IR opposing these effects, impacting neuronal excitatory projections [90]

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LAURA: Por supuesto

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