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This approach falls outside the Summary of Product Characteristics (SmPC) dosing regimens and is not supported by UK guidance

Do not exceed the recommended dosage

We also observed that the median time to onset of GLP-1 RAs-associated acute pancreatitis was 92 (range: 03,312) days across ICSRs that provided both drug initiation and AP onset times, and 2.5 months of the case series, indicating a longer onset duration compared to other gastrointestinal adverse events triggered by GLP-1 RAs (Zhou et al., 2022)

This is another issue of concern with long-term use of melanocortin agonists [60,61]