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49 It is interesting that the double Aib substitutions led to comparable receptor binding and potency (IC 50 = 1.1 nM, EC 50 = 0.06 nM compared to GLP-1 (IC 50 = 1.5 nM, EC 50 = 0.08 nM)), whereas a single Aib at position 8 brought in a 4-fold decrease in potency and 2-fold increase in binding affinity

These additional compounds each require independent calculation, expanding the planning needed but not changing the fundamental math for any single peptide

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[10] [11] Similarly, the SURMOUNT-4 trial showed significant weight regain after tirzepatide discontinuation

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Other medications, such as certain diuretics, might lower potassium