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A novel GSTP1 and multidrug resistance protein 1-mediated NO storage and transport mechanism (MRP1/ABCC1) protects an M1-macrophage model from the effect of NO (149-153)

Nutrients 17, 3030

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GLP-1 Receptor Activation Metabolic Regulation GLP2 activates GLP-1 receptors with lower potency than endogenous GLP-1 but demonstrates biased signaling properties: Preferential cAMP pathway activation over beta-arrestin recruitment, which may enhance insulin secretory responses Suppression of inappropriately elevated glucagon secretion during hyperglycemia Reduced GLP-1 receptor internalization compared to native GLP-1, potentially extending signaling duration Contribution to glucose-dependent insulin secretion complementary to GIP receptor effects Research in isolated pancreatic islets demonstrated that GLP2s insulinotropic actions depend on GIP receptor presence, with the biased GLP-1 receptor signaling providing synergistic enhancement

doi:10.1016/j.jhsa.2017.01.011 [DOI] [PubMed] [Google Scholar] 30.Memeo A, Loiero M