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Autophagy is initiated by the autophagy-activating protein complex that includes the UNC-51-like kinase (ULK1), autophagy-related protein 13L (ATG13L), family interacting protein of 200 kDa (FIP200), and ATG101 [254]

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Patients who lose 510% of body weight typically see additional cholesterol improvements beyond the direct GLP-1 effects, creating a synergistic benefit

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Second, it communicates directly with the hypothalamusthe part of the brain that regulates hungerto reduce intense cravings and silence the constant thoughts about food, often referred to as food noise. Finally, it stabilizes blood sugar spikes, which helps prevent your body from actively storing excess fat