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Manifestations of the main AITDs are described in the following sections

NRF2 orchestrates the upregulation of several antioxidant genes reliant on GSH, including GSR, solute carrier family 7 member 11 (SLC7A11), glutamatecysteine ligase catalytic subunit (GCLC), and glutamatecysteine ligase modifier subunit, as well as metabolic detoxification genes such as aldehyde dehydrogenase 1 family member A1 and aldoketo reductase family 1 member C1 in cancer cells [66]

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DOI 10.1002/14651858.CD0017555.pub2 Falsini B, Piccardi M, Minnella A, et al

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