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In diabetic rats, trigonelline controls key enzymes involved in the metabolism of glucose and lipids, including glucokinase, glucose6phosphatase, fatty acid synthase, and carnitine palmitoyl transferase

NIX/BNIP3L has been shown to be involved in the PINK1-parkin pathway, being ubiquitinated by parkin and recruiting the mitochondrial phagocytosis receptor, NBR1, for mitochondrial degradation [17]

In mouse studies, PTD-DBM promoted hair regrowth in alopecia models and demonstrated the ability to stimulate new follicle formation, something most treatments cannot do

F.SattarN.PreissD.et al (2019)

doi: 10.1080/17425247.2019.1645118

Its role as an antioxidant that can protect against oxidative stress is well established