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For the IPGTT, mice were fasted for 6 hours before injection of glucose at 2 g/kg/BW

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All animal procedures were carried out in accordance with ARRIVE guidelines and approved by the Biomedical Ethics Committee of the Health Science Center of Xian Jiaotong University (XJTUAE2025-415)

Tesamorelins GHRH receptor activation triggers cAMP-PKA signaling cascades that elevate IGF-1 for 812 hours, long after plasma peptide is undetectable

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