The primary endpoints were clinical remission for UC patients (mMS 2) and endoscopic response for CD patients (50% SES-CD reduction), with inclusion criteria requiring IBD diagnosis for 3 months, moderate to severe disease activity, and inadequate response to prior therapies, while excluding patients with active infections, malignancy, immunocompromised states, or pregnancy
A schematic of the experimental workflow for the proteomics experiment can be found in Fig
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Animals were cared for in accordance with the Guide for the Care and Use of Laboratory Animals , 8 th edition
Among the chemical penetration enhancers, a prominent category includes adjuvants based on Hyaluronic acid (HA), a polysaccharide composed of alternating monomer units of N-acetyl glucosamine and glucuronic acid, with an average molecular weight of 2 10 5 to 1 10 7 Da [122]