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Do not use in patients with known hypersensitivity to Hydroxocobalamin or cobalt

The doses used in trials were around 500ug/kg, which means a 100kg person was receiving 50mg of the peptide daily. $50 million in research and development down the drain for a promising product that was no longer a viable pharmaceutical product

Options include partial reconstitution (if feasible with your vial format), freezing portions of reconstituted solution (accepting some potency loss), or adjusting your dose higher to use everything before expiration

Mahmoud AZB, Makhdoom AN, Mufti L, Alreheli RS, Farghal RG, Aljaouni SE

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The 28-day rule why exactly 28 days The 28-day window comes from Pfizer/Hospira prescribing information for bacteriostatic water for injection