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For eyes with centre-involved DMO and visual acuity 20/25 or better, laser or aflibercept was not superior to observation, provided either the laser or observation eyes were given aflibercept for visual acuity decline if DMO persisted, with decline defined as at least ten letters (two lines on a standard eye chart) of visual acuity compared with a previous visit or five to nine letters (one to two lines) of visual acuity at two consecutive visits compared with a previous visit 228 (Fig

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Updated February 25, 2026