(n=50) found that tesamorelin produced a mean reduction in visceral adipose tissue (VAT) of -34 cm versus a gain of +8 cm on placebo (net treatment effect -42 cm, P=0.005)
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Notably, mutations in TP53 not only change its conformation but also cause p53 aggregation, and p53 aggregation in cells is more consequential than conformational changes
MCAS is a type of mast cell activation disorder (MCAD) characterised by an abnormal activation of mast cells resulting in chronic multisystem polymorbidity of a general inflammatory nature, with or without an allergic nature
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