Implications for employers: Many of those who stop GLP-1 medications do so because they do not have coverage and cannot afford to continue
Is the patient protecting muscle as weight decreases
If patients stop retatrutide, weight returns
The most commonly reported side effects were gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, which were generally mild to moderate and occurred mainly during dose escalation
These may include symptoms such as nausea, changes in bowel habits, or reduced appetite, particularly during early treatment phases or following dose adjustments
As patients lose weight and improve glycemic control, alterations in insulin sensitivity, leptin levels, and other metabolic hormones could potentially affect taste perception