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Available from: Chen L, Chetkovich DM, Petralia RS, Sweeney NT, Kawasaki Y, Wenthold RJ, et al

PTHrP 136 exerts an anabolic action to bone, including enhanced bone histological features and raised osteoblast differentiation markers in the long bones and plasma in mice [57]

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We speculate that because energy metabolism is dependent on NAD + and its reduced form NADH, a decline in the total NAD + content will lead to depressed energy metabolism, and NAD + supplementation will prevent that

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Zhang YG, Guo X, Xu P, Kang LL, Li J: Bone mesenchymal stem cells transplanted into rabbit intervertebral discs can increase proteoglycans