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This systematic review of data on disability-associated outcomes for all forms of schistosomiasis shows that the disease is significantly associated with anaemia, chronic pain, diarrhoea, exercise intolerance and undernutrition, suggesting that the disability burden previously assigned to schistosomiasis by the WHO is an underestimate and indicating a need to reassess priorities for treating this silent pandemic
In vivo niches, SCs are present under hypoxic conditions and change in oxygen levels can induce oxidative stress, which can influence SC phenotype, proliferation, fate, pluripotency, etc., Therefore, in vitro culture conditions used to study MSCs should be maintained similar to their in vivo niches.[44] Combinational therapy using both platelet-rich plasma injections and stem-cell therapy PRP and SC therapy is continuously studied for their regenerative benefit in wound healing, sports medicine and chronic pain treatment
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