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Indeed, in both studies, the highest frequency of TEAEs was in the normal function groups, possibly owing to the smaller sample sizes in the more severe impairment groups, or alternatively because participants with more serious health concerns, such as those with severe renal or hepatic impairment, may be less likely to notice or report mild or moderate TEAEs, as observed in populations with cancer [21]
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Extracts from insect (53, 62) and mammalian cells (53, 62) transfected with adiponutrin possess functional TAG lipase activity that requires the active site serine (G X S X G motif) when assayed in vitro (62)
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FcRn antagonists likely block transplacental transport of IgG, as demonstrated for nipocalimab in an ex vivo placental transfusion model [341], and are unlikely to pass to the fetus, as the high affinity and limited pH-dependency of their binding to FcRn cause them to stay within FcRn-expressing cells, and not undergo extensive receptor-mediated transport
