When GH binds those new receptors, an enzyme called JAK2 fires and turns on the genes that build new tissue
The resolution of this apparent paradox is that glucagon receptor activation also drives energy expenditure through two well-documented mechanisms: Thermogenesis: GCGR activation in brown adipose tissue (BAT) and, to a lesser extent, skeletal muscle increases uncoupled heat production, raising resting energy expenditure
Eating regular meals, even if portions are smaller due to reduced appetite, helps maintain digestive rhythm
The evidence points to yes, but with important details
Participants using GLP-1 medication lost up to 9 times more weight than diet and exercise support alone
10.1038/s41551-016-0007 59 DongJ.SakaiK.KomaY.WatanabeJ.LiuK.MaruyamaH.et al (2021)