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My resting heart rate went up a little (enough for my Oura ring to notice) and my perceived effort during exercise was higher during the 3-4 days of highest effectiveness

It is essential for vegans, older adults, and athletes

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They found that at the highest dosage of 4.8 mg survodutide weekly, study participants lost 14.9% of their body weight in comparison with a placebo group (2.8% weight loss) [122]

Drug-induced oxidative stress and toxicity

Chronic high-dose vitamin B intake (generally in gram quantities daily over many months) has been linked to severe sensory neuropathy characterized by numbness, impaired proprioception, and paresthesia in a stocking-glove distribution