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Regulatory agencies and weight loss specialists recommend evidence-based monotherapy or dual compounds (like semaglutide plus tirzepatide in a single medication) rather than two separate drugs

61,62 One of the major limitations of this study was the low number of patients and the absence of a placebo arm, prompting a placebo-controlled AST-120 Used to Treat Mild Hepatic Encephalopathy (ASTUTE) clinical trial, 63 a multicenter, double-blind RCT that randomized 148 patients with compensated cirrhosis to receive either dose-ranging oral AST-120 (2 or 4 g three times per day) vs

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Lancet 391 , 11741185 (2018)