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However, many people experience dramatic improvement or near-complete resolution of symptoms by addressing root causes: healing gut inflammation to restore DAO production 24 , supporting methylation for HNMT function, stabilizing mast cells, and identifying personal triggers

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15,16 On the other hand, TRX reductase (TRXR) utilizes NADPH as an electron donor to maintain the reduced form of TRX, which contributes to scavenge H 2 O 2 and reduce ribonucleotide reductase (RNR) for DNA synthesis

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This suggests that ghrelins polymorphisms are closely associated with vulnerability to IBS development and may contribute to the pathogenesis of IBS (139, 140)