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Blocking lipid peroxidation also increased complex I and II activity and the overall efficiency of ETC coupling to ATP synthesis (as measured by the ratio of State III/IV O 2 consumption: RCR)

Subsequently, the cells were treated with LAbs@Lip@Rapa, Lip@BMn/Rapa, and LAbs@Lip@BMn/Rapa for another 2 h

Among them, the glutamate produced by the decomposition of glutamine via GLS not only provides the raw material for the synthesis of GSH but is also further metabolized into -ketoglutarate (-KG) in the mitochondria under the action of glutamate dehydrogenase (GLUD1) or transaminases and then enters the tricarboxylic acid cycle to produce ATP [29]

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One compound tried to bypass appetite regulation entirely and got outcompeted by biology

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