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Clinical Orthopaedics and Related Research, 2000
Research from the STEP programme (semaglutide), SCALE studies (liraglutide), and SURMOUNT trials (tirzepatide) consistently demonstrates significant reductions in waist circumference, which correlates with abdominal fat loss
For me, this was a substrate and cofactor story, not an oxidative stress story
Met activation is known to trigger a downstream signalling cascade involving phosphorylation of signature proteins (Fig
In fact, reduced expression of excitatory amino acid transporter (EAAT2) and glutamate synthetase (GS) transcripts, which are localized in glia, have been reported in CSDS mouse model of depression (116, 130)