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Eye Health Concerns Emerging research suggests a possible link between GLP-1 use and neovascular age-related macular degeneration (AMD), a leading cause of blindness

Until then, decisions about emerging weight management therapies should be guided by robust scientific evidence rather than online claims or early expectations

Research shows that most people re-gain at least a portion of their weight back after discontinuing the medication

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Direct and Metabolite Effects: While direct GLP-1R expression on -cells is low, degradation products of GLP-1, such as GLP-1(9-36) , may also inhibit glucagon secretion by activating inhibitory G proteins (Gi/o) and modulating calcium channels (Zheng et al., 2024)

"A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease (TRIUMPH-3) - Lilly Clinical Trials"