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Despite these positive findings, the study is not without its limitations

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In general, mB12/LDFA treatment had a significant effect on glutathione and cysteine metabolism with a medium effect size while BH4 had a significant effect on methylation and markers of chronic oxidative stress with a large effect size

The analysis of enriched loci (peaks) indicating ACTL6A binding revealed, as expected, a prominent peak (GRCh38:6:53545016:53545243) near the transcriptional start site (TSS) of GCLC (Fig