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Combination of Insulin with a GLP1 Agonist Is Associated with Better Memory and Normal Expression of Insulin Receptor Pathway Genes in a Mouse Model of Alzheimers Disease

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Furthermore, acute exposure of isolated mouse islets or INS-1(832/13) -cells to the oxidative stressors, arsenite, 4-hydroxynonenal, or methylglyoxal, decreased insulin secretion ( Circulating metabolites, like -hydroxybutyrate that enter cells and increase NADH and ROS production in -cells, increase insulin secretion (Figure 6A)