Histologic patterns of injury: Acute hepatocellular injury/hepatitis (seen in 90% of DILI): Hepatocellular necrosis Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply
In the mentioned semaglutide dosing study, adverse events (side effects) occurred in 43.5% of placebo recipients (the so-called nocebo effect wherein people taking placebo still report side effects)
He acknowledges the research limitations, noting that much evidence comes from animal studies rather than human clinical trials
This builds on his work to understand 'how circulating GLP-1 can produce multiple actions, both directly and indirectly, on multiple organs' which he has pursued for many years with colleagues (McLean, Wong, Campbell)
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42 Addressing the gaps in DN epidemiology requires coordinated efforts to improve research methodologies and promote international collaboration to develop effective prevention and treatment strategies
