Efficacy and Safety of Setmelanotide, an mc4r Agonist, in Individuals With Severe Obesity Due to Lepr or Pomc Deficiency: Single-Arm, Open-Label, Multicentre, Phase 3 Trials
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They draw water into the bowel, softening stools and increasing frequency Bulk-forming laxatives (ispaghula husk, methylcellulose) work similarly to dietary fibre and are generally suitable for long-term use, but should be avoided if you have severe bloating or suspected impaction Stimulant laxatives (senna, bisacodyl) should be reserved for short-term use when other measures fail Rectal treatments (glycerol suppositories, small-volume enemas) can provide rapid relief for occasional constipation Establishing a regular toilet routine can be beneficial
These medications mainly work in the following ways: Appetite Suppression: GLP-1 helps regulate appetite by acting on the brain
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Tagging expert in this area John Jakicic who participated in an excellent diaTribe Musing panel on maintaining dietary health and lean muscle mass while on AOMs