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Moos WH, Faller DV, Glavas IP, Harpp DN, Kamperi N, Kanara I, et al

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In addition, calcium is necessary for muscle contraction and even a short-term deficiency can cause muscle cramps, stiffness, and poor mobility

Laboratory investigations have reported measurable changes in nitric oxide related signaling markers, endothelial migration assays, fibroblast gene expression profiles, and cytoskeletal reorganization markers in cell culture and animal models