10.1021/cb400184v 27 GauseG
8 of 22 participants (36%) experienced mild treatment-emergent adverse events which were transient and self-limited
One of the most commonly cited trials (Arjinpathana & Asawanonda, 2012) used 500mg per day over 4 weeks and reported a significant reduction in melanin index versus placebo
While eating less helps with weight loss, it can also mean too little protein, B vitamins, or hydration , all of which support brain function
Like all medications, it carries potential side effects and risks
relatively large apparent volume of distribution of ~2-3 L/kg in horse, cows, sheep & dogs reflecting its relatively high lipid solubility in dogs, xylazine is metabolized by the liver to ~20 metabolites, with only 8% eliminated unchanged in the urine, (Rector et al, 1996