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It can act on enterocytes and underlying tissue directly from the luminal side

Ferroptosis: A novel anti-tumor action for cisplatin

Lord, J.C

The content of GSH, reduced GSH, and oxidized GSSG was measured using the method described by g for 10 min at 4C, and the clear supernatant was collected and used for the total GSH assay in 96-well microtiter plates

Combined, these effects can produce clinically significant cardiovascular stress, particularly in patients with pre-existing heart conditions or uncontrolled hypertension