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FUNDING None ACKNOWLEDGMENTS None NOTES Fig

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The early or acute stage can last from 6-18 months

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PT-141's central action means it can enhance multiple dimensions of sexual function: Increases sexual desire and motivation - the psychological wanting of sexual activity Enhances subjective arousal and pleasure through effects on brain reward circuits Facilitates physiological genital arousal through central activation of autonomic pathways Pharmacokinetics The peptide's effects develop within 30-45 minutes of subcutaneous administration, corresponding to the time required to cross the blood-brain barrier and activate central melanocortin receptors