if semaglutide didn't work will tirzepatide Unresponsive to If Semaglutide didn't work for

Once the patient is at a point where they're losing weight in a slow, consistent, healthy way, then we keep them on that dose until we've reached their goal weight, and then we slowly taper the medication off, Levites said

Pramlintide as an adjunct to insulin therapy improves long-term glycemic and weight control in patients with type 2 diabetes: a 1-year randomized controlled trial

Most healthcare providers recommend a structured dose reduction over 8 to 16 weeks for the best long-term outcomes

Specifically, thyroid function should be rechecked 6-8 weeks after starting or titrating GLP-1 therapy, after significant weight loss, or after any levothyroxine dose change

That would put you at risk of undereating, which can result in nutrient deficiencies and muscle loss

2024;84:802-810.e6