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Key References Jastreboff AM, Kaplan LM, Fras JP, Wu Q, Du Y, Gurbuz S, et al

A new addition to the GLP-1 medication group is retatrutide

In many cases, patients who lose a lot of weight experience such dramatic skin stretching that theyre left with extra folds of skin

Psychological & Physiological Dependence Patients may develop a psychological or physiological reliance on GLP-1 medications, complicating the discontinuation process

Thus, it cannot be excluded that in some IBD patients disruption of GI tract homeostasis may be observed leading to development or exacerbation of IBD

While natural GLP-1 rarely causes problems, pharmaceutical GLP-1 agonists commonly cause gastrointestinal side effects including nausea, vomiting, diarrhea, and constipation, particularly during dose escalation