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Materials and methods Cell culture The human pancreatic cancer cell lines (CFPAC-1, SW1990, PANC-1, and BxPC-3) and murine pancreatic cancer cell line (Pan02) were procured from the Cell Bank of the Chinese Academy of Sciences Type Culture Collection (Shanghai, China)

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MEK inhibitors, novel anti-adhesive molecules, reduce sickle red blood cell adhesion in vitro and in vivo, and vasoocclusion in vivo