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There is no single correct amount more water simply spreads the same 70 mg of peptide across a larger volume, which makes small doses easier to measure accurately
The applicant added that the single serious adverse event observed during the study occurred in the standard of care reusable arm and that the authors noted that patients in the reusable cystoscope group reported significantly higher pain with urination post-procedure
Adverse effects observed in clinical trials include: Gastrointestinal effects: nausea, vomiting, diarrhoea, and constipation particularly during dose escalation
Mechanistically, intra-articular AOD-9604 may stimulate synovial fibroblast proliferation or reduce inflammatory cytokine production in the synovial microenvironment, though direct effects on cartilage are unclear
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