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Deficiency of Se in the serum of patients with GD increased with age and was correlated with an increased titer of antibodies to the TSH receptor (TRAb)

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In addition, KG is a cofactor for the Fe(II)/2-oxoglutarate-dependent dioxygenases (OGDD), including Jumonji-domain (JMJC)-containing histone demethylases, ten-eleven translocation (TET) DNA demethylases and hypoxia-inducible factors (HIF)-prolyl hydroxylases (PHD) essential for HIF-hydroxylation and consequent degradation [70]