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They stated: "The 2-D method can be used for any breed, but direct extrapolation of our normal values should not be made to other breeds, because the heart has a slightly different appearance in various breeds reflecting variability in size, shape, and position within the thorax." The 2002 study's authors also were careful to exclude any findings comparing LA/Ao ratios of dogs with and without enlarged hearts

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Serious B12 deficiency may cause anemia and nerve damage