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[3] After oral administration, peak plasma concentrations are usually achieved within two hours

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It should be noted that only semaglutide injection (not oral) was compared to tirzepatide, and higher doses of semaglutide were not compared to tirzeparatide.[21] The mean A1c reduction from baseline was above 2% and weight reduction was near 10 kg (22 lbs) in tirzepatide clinical studies, exceeding current FDA-approved GLP-1 products