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25 Ascorbate is an excellent antioxidant in cells, not only because of its relatively high concentration but also because of the high rate constant of its reaction with free radicals

doi: 10.1159/000027477

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study, CNS malignant melanoma is more likely to be primary if one or more of the following factors are present: a single intracranial lesion, a lesion with intramedullary or leptomeningeal involvement, a pituitary or pineal lesion, a lesion with hydrocephalus, and/or a lesion without malignant melanoma outside the CNS [19]