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Confirming the activity of the enzyme in mammalian cells, ectopic expression of a codon-optimized GshF cDNA in HEK-293T cells increased cellular GSH levels and conferred resistance to the BSO treatment (Fig

Two kinds of UA are present in human blood: urate ions, and acid urates, such as ammonium acid urate

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It causes a lot of loss of electrons which then creates a lot of free radical stress and damage

doi:10.1038/npp.2012.112 Mischoulon, David, and Maurizio Fava