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The incretin defect is due to the nearly complete loss of the insulinotropic effect of GIP, whereas the secretion of GIP is normal

In experimental studies, it has been shown to enhance healing of various wounds, including gastric ulcers, skin, cornea, muscle, colon-colon anastomosis, colo-rectal fistula, and segmental bone defects

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Protocol 3: the twice-weekly split dose approach Goal: Flatten the concentration curve to eliminate end-of-week symptom return Schedule (any compounded GLP-1): Take half your weekly dose every 3.5 days (e.g., Monday morning and Thursday evening) Total weekly dose remains identical Escalate total weekly dose at the same rate as your original plan Why the plotter supports this: The plotter shows a dramatic difference between once-weekly and twice-weekly dosing curves at the same total weekly dose

the FDA also notes these reports are likely underreported because state-licensed 503A pharmacies are generally not required to submit adverse events to FDA