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10.1124/jpet.114.220350 53 Heckman-StoddardB

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Alison Cave, MHRA's Chief Safety Officer, stated, "While the risk of serious side effects is very low, it is important that patients and healthcare professionals are aware of the symptoms and remain vigilant." She added, "We advise anyone using GLP-1 class drugs who experiences persistent abdominal pain, accompanied by nausea and vomiting, to consult a healthcare professional."

In the D-Gal + FOXO4-DRI group, mice also received D-galactose injections and, after 4 weeks, were given intraperitoneal injections of FOXO4-DRI (5 mg/kg, MCE, HY-P4157) every 2 days for 4 weeks, followed by tissue collection