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In MCAS or histamine intolerance, these cells are hyperactive, leading to chronic symptoms like: Hives and skin flushing Brain fog or fatigue Digestive issues Headaches or dizziness Temperature intolerance This immune overreaction isnt just frustratingits exhausting

Dosing typically starts at 0.6 mg and titrates up to 3 mg over several weeks

Metabolites (2022) 4:348

Melena generally starts much higher up in the digestive tract and results in black, tarry stools

Rare but Possible Side Effects With any medication, theres always a risk of rare but possible side effects

But early investment in support pays dividends in long-term outcomes