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On the one hand, abnormal remodeling and angiogenesis in subchondral bone can destroy articular cartilage
doi: 10.1038/s42255-019-0073-4 188 YoshinoMYoshinoJKayserBDPattiGJFranczykMPMillsKFet al
Additionally, literature has reported that ALA can inhibit RANKL-induced osteoclastogenesis via the FFAR4/arr2 signaling pathway and prevent inflammation, which is consistent with the findings of this study [37]
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This timeframe provides adequate opportunity to work through initial side effects, optimize dosing, and establish long-term lifestyle changes that support weight maintenance
Statistical analysis All statistical analyses were conducted using R (version 4.4.2), with the metafor package used for meta-analytic modeling
