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This is precisely why protein intake and resistance training are not optional during GLP-1 therapy

We thank Jiri Damborsky for providing insights into early versions of the model

Exercise priorities may shift

(viii) improve mitochondrial dysfunction that has been associated with IR and (ix) achieve -cell function preservation (both in patients with T2D and individuals with prediabetes) and suppress excess intra-pancreatic fat deposition [44, 45, 5764] (Figure 1)

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TNF-alpha induced shedding of the endothelial glycocalyx is prevented by hydrocortisone and antithrombin