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Moreover, DOX/aNLG919-loaded CaCO 3 nanoparticles (DNCaNPs) obtained by combining the ICD inducer DOX and the IDO1 inhibitor alkylated NLG919 can induce ICD in cancer cells and can induce effective anti-tumor immune responses by inhibiting IDO1 to limit the production of immunosuppressive kynurenine thereby leading to increased tumor cytotoxic CD8 + T cell infiltration and immunosuppressive Tregs depletion, and the combination of chemotherapy and immunotherapy with this nanoparticles can effectively inhibit tumor growth (168)

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48 In addition, several structural mutations not only destabilize proteins but also impair the interactions between DNA and proteins

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Adipose tissue is the bodys primary way of storing excess energy