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Treatment with Mazdutide is associated with marked reductions in systolic blood pressure and improvements in blood lipid profiles, contributing to heart health

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doi:10.1530/EJE-19-0167 Eng J et al

In addition, the tubular ultrafiltrate from nephrotic rats stimulated collagen types I and IV synthesis in cultured tubular cells, suggesting that the excessive losses of IGF-1 in the nephrotic state may promote tubular-interstitial fibrosis and thereby, progressive kidney disease in patients with persistent nephrotic syndrome [219]