In aged skeletal muscle models, NNMT inhibitor treatment increased proliferating/active muscle stem cells by 60-75% following injury, myofiber cross-sectional area increased 1.8-fold at one week post-injury with high-dose treatment, and peak torque of injured muscle increased by 67% compared to control (p = 0.033), with no untoward systemic toxicity observed in plasma chemistry markers (Neelakantan et al., 2019)
When NNMT is inhibited, research suggests the opposite begins to happen cells shift toward burning fat as fuel rather than holding onto it
Serotonin can then be converted into melatonin with the help of a SAM-dependent methylation reaction this again shows an interconnection to the methionine cycle
You get the full dose every time, with no guessing about how much your body actually used
It provides a highly reliable baseline for in vitro and controlled preclinical research
Doing this will give you a better idea of the severity of a B12 deficiency (if there is one) and how much B12 you should be taking on the reg