Do you expect the trend to continue and market access to ease more
It is difficult to evaluate the extent to which glucose-independent mechanisms are involved in renoprotection by GLP-1RAs
Patients on tirzepatide lost an average of 20.2% of their body weight over 72 weeks Patients on semaglutide lost an average of 13.7% of their body weight over the same period 47% more tirzepatide patients achieved 25% or greater body weight loss compared to semaglutide Tirzepatide also produced greater reductions in waist circumference across all dose comparisons A 2024 meta-analysis published in JAMA Internal Medicine analyzing real-world data from over 140,000 patients confirmed the same pattern: tirzepatide produced an average of 4.23 kg more weight loss than semaglutide across all doses and durations studied
However, reports have raised concerns about the potential association between these medications and an increased risk of depression and suicidal ideation
In humans, a Mediterranean diet rich in olive oil led to higher post-meal GLP-1 levels, improved insulin sensitivity, and lower fasting and post-meal blood glucose levels compared to a diet high in saturated fats
Saxenda (Liraglutide) Saxenda might sound familiar because it shares a similar approach to Wegovy